Multi-dose activated charcoal was added to the treatment regimen to decrease absorption and enterohepatic recycling of the cardiac glycosides, e.g., digoxin from the Digitalis purpurea leaves in the patient’s GI tract. The patient initially received treatment with digitoxin-specific Fab fragments. reported on a suicidal patient who ingested Digitalis purpurea (Foxglove) leaves. The patient received treatment with activated charcoal, vasopressors, and diazepam. reported on a suicidal patient who ingested a large dose of chloroquine and diazepam. The investigators believe that the activated charcoal treatment shortened the elimination half-life of lamotrigine by decreasing enterohepatic recycling.

Multiple doses of activated charcoal were used for treatment. reported two cases of lamotrigine overdose. Multiple-dose activated charcoal (MDAC) is often a consideration in cases of life-threatening ingestions of carbamazepine, dapsone, phenobarbital, quinine, and theophylline.

The ingested toxin is known to be adsorbed by charcoal (see below)

Paracetamol overdose antidote